I've heard this prediction a few times over the years. And now it seems to be finally happening. Let's start with a ZDNet report from July:
Why popular antivirus apps 'do not work'
which reveals that antivirus apps are largely useless against new trojans and viruses.
Then Info World's Roger A. Grimes asked in Sept:
Is the end of anti-virus finally here?
Now we have the CTO of BigFix who declares:
Anti-virus is Dead!
"Stand-alone, signature-based, anti-virus is dead. The stand-alone anti-spyware market is over too, if it even existed!"
On my systems, I dumped Norton Antivirus a few months ago because it seems to sap resources, and its product activation annoys me. I now use AVG Free Edition and the built-in Windows XP firewall. For anti-spyware I use AVG Anti-Spyware ( from the same company) plus I run the old standbys, Ad-Aware and Spybot occasionally.